A leader peptide is sufficient to direct mitochondrial import of a chimeric protein.
نویسندگان
چکیده
منابع مشابه
Arginine in the leader peptide is required for both import and proteolytic cleavage of a mitochondrial precursor.
Most mitochondrial proteins are encoded in the nucleus and translated in the cytoplasm as larger precursors containing NH2-terminal "leader" peptides, which are strikingly basic in overall amino acid composition. Recent experiments indicate that these leader peptides are both necessary and sufficient to direct post-translational recognition and import of precursors by mitochondria. In this repo...
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References 10gren, w. L. (1984) Annu. Rev. Plant. Physiol. 35,415--442 2 Hardy, R. W. F., Havelka, U. D. and Quebedeaux, B. (1978) in Photosynthetic Carbon Assimilation, (Siegelman, H. W. and Hind, G., eds), pp. 165-178, Plenum Press 3 Mclntosh, L., Poulsen, C. and Bogorad, L. (1980) N ~ r e 288,556--560 4 Miziorko, H. and Lorimer, G. H. (1983) Annu. Re¢. Biochen.. 52,507-535 5 Cashmore, A. R. ...
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Mitochondria import most of their proteins from the cytosol. Precursor forms of most matrix proteins as well as some IM and IMS proteins are synthesized on cytoplasmic ribosomes with N-terminal cleavable signal sequences. Many other mitochondrial proteins including IM carrier proteins contain internal targeting sequences. Three multisubunit translocases, one in the OM and two in the IM, partici...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 1985
ISSN: 0261-4189
DOI: 10.1002/j.1460-2075.1985.tb03750.x